Steam version or disc or both? Up until Quake 3 (I believe) Carmack programmed these games so that they would run in Win NT, and if it didn't work in NT, well... Probably some of the best backwards compatible games there are. WTF is Windows 7,8,10 doing that can break these games? Still running Vista so I haven't heard of this before now.
WTF you running VISTA for holy shit batman