Not for multi-monitor resolutions. [H] showed the 2Gb of ram was crippling the GTX680 in 5760x1080 resolution when the aliasing was turned up.
http://www.hardocp.com/article/2012/03/28/nvidia_kepler_geforce_gtx_680_sli_video_card_review/9
The biggest question in regards to performance and gameplay experience about GeForce GTX 680 SLI was if the 2GB of VRAM per GPU and lesser memory bandwidth compared to Radeon HD 7970 would be a hindrance. Our testing has clearly answered that question. In fact, in every game we tested, GTX 680 SLI offered a better gameplay experience compared to Radeon HD 7970 CrossFireX. We specifically tested at NV Surround and Eyefinity at the maximum resolution of our configuration at 5760x1200 to see if there would be any bottlenecks. We found that the new GeForce GTX 680 SLI has the performance where it counts.