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It would mostly LOOK funny but would be OK if the drivers and cross-over frequencies match but speakers are different brands. Doing this with two different speakers is more trouble than it is worth since you'd need a calibration mic and software to test each speaker to see if their response curves are a close match.
Now. If we are talking adding two different speakers to an existing 2.1 setup, then that would be OK and is done quite often in the case of surround speakers. Any kind of room correction built into a piece of A/V gear or using something like a Umik-1 and REW would handle correcting each speaker for room acoustics. Here is an article on the subject...
https://www.minidsp.com/applications/acoustic-measurements/umik-1-setup-with-rew
The System that I ordered is Cyber Acoustics CA3602.....https://www.amazon.com/Cyber-Acoust...pID=51VxCb56DRL&preST=_SY300_QL70_&dpSrc=srch
DSP is not a viable solution for room acoustics. It can help a little but the root problem will remain.