BIOS flashing, especially for AMD cards, is so easy I actually prefer it over software solutions. Maybe use software to find your card's happy place, but then flash it at those settings so you don't need to mess with it any more.
If you decide to go the software route, you will have to watch though because some Sapphire models lately have not exposed their voltage modification functionality to Afterburner. For that, you are stuck using Sapphire Trixx.