For example, while certainly an interesting project, I'm sure no one would suggest I do what this guy did:
http://www.servethehome.com/category/the-big-whs-30-drive-whs/
and use Windows Server 2008 R2 as the Host. I assume I'd want to have whatever file server OS I'm using installed on the bare metal.
Yea that guy is a loon and a nut IMO.
Honestly, I use that thing for storing tons of witness prep video. The nice thing is that it is SUPER easy to maintain. The bad thing is that it has since grown to a second 4U Norco box to hold test drives for playing with VM's and such. It actually passed 60TiB raw last week, and added a few SSD's.
Bottom line: don't use that for tons of users at work. The commercial dedupe and etc packages are pretty good. On the other hand, if you need some sort of temporary storage at work, it is a pretty sweet setup. You could fairly easily setup a box for a few grand as a temporary storage pool.
I know... I need to update the log. Been busy buying a new road bike so my post-work cycles have been dedicated to that front. Somewhat like that server, I started with a $1k budget last Friday morning, and by the time I left the bike shop today the damage was over $4k